Response to ozone

Across TCGA patient cohorts, RNA activity of the Response to ozone pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNRC6B_S879, ACIN1_T902, and SP4_S46, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ozone activity versus TNRC6B_S879 in BRCA (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNRC6B_S879 →	-0.442	-0.075	.003	.006	3	6
HNSC	ACIN1_T902 →	-0.768	-0.110	.008	.001	3	6
HNSC	SP4_S46 →	-0.584	-0.131	<.001	<.001	3	6
HNSC	CCNL1_S352 →	-0.458	-0.094	<.001	<.001	3	6
PDAC	BAG4_S179 →	-0.832	-0.069	.002	.002	3	6
COAD	TRMT112 →	-0.150	-0.060	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010193 vs TNRC6B_S879 — BRCA

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