Response to ozone

Across TCGA patient cohorts, RNA activity of the Response to ozone pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRL, CHRNE, and TACR1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ozone activity versus PDGFRL in GBM (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PDGFRL →	-1.351	-0.458	<.001	.001	3	2
GBM	CHRNE →	+0.442	+0.382	.001	<.001	3	2
GBM	TACR1 →	+2.425	+0.384	<.001	<.001	3	2
GBM	LEF1 →	-1.219	-0.493	.009	.005	3	2
GBM	SFR1 →	+0.747	+0.409	<.001	<.001	3	2
GBM	PLCD3 →	+0.813	+0.476	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010193 vs PDGFRL — GBM

Explore this scatter interactively →