Response to ozone

Across TCGA cell cohorts, RNA activity of the Response to ozone pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNB5, PEAK1, and MIGA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNB5 grouped by Response to ozone-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GNB5 →	-1.550	-1.938	.005	<.001	3	4
SOFT_TISSUE	PEAK1 →	-1.415	-1.157	.002	.007	3	4
LIVER	MIGA1 →	-0.851	-1.462	.009	.003	3	4
BLOOD_Leukemia	EIF5A →	+0.879	+1.552	<.001	<.001	3	4
LUNG_SCLC	REXO1 →	+0.581	+0.942	.001	.009	3	3
LUNG_NSCLC_LUSC	EPM2A →	-0.715	-0.357	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNB5 by Response to ozone activity — LIVER

Explore this box plot interactively →