Sugar mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Sugar mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ROBO4_S823, SCIN, and ZMYM3_S464, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sugar mediated signaling pathway activity versus ROBO4_S823 in OV (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ROBO4_S823 →	+1.055	+0.123	.001	.001	3	4
LSCC	SCIN →	-0.694	-0.072	.001	.004	3	4
COAD	ZMYM3_S464 →	+0.368	+0.058	<.001	<.001	3	4
BRCA	NUP93 →	+0.160	+0.044	.002	.003	3	4
CCRCC	COL7A1 →	-1.170	-0.091	.007	.001	3	4
GBM	ID4_S5 →	+0.673	+0.063	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010182 vs ROBO4_S823 — OV

Explore this scatter interactively →