Sugar mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Sugar mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM81, WWC2-AS2, and SOX4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sugar mediated signaling pathway activity versus TMEM81 in UCEC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM81 →	+0.459	+0.566	.005	.008	3	5
PDAC	WWC2-AS2 →	-0.189	-0.649	.005	.007	3	5
GBM	SOX4 →	+0.642	+0.377	.008	.007	3	4
GBM	ZSCAN9 →	+0.373	+0.613	<.001	.001	3	4
GBM	ATAT1 →	+0.411	+0.499	<.001	<.001	3	4
BRCA	SAMD1 →	+0.432	+0.721	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010182 vs TMEM81 — UCEC

Explore this scatter interactively →