Sugar mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Sugar mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD13, SKAP1, and TLE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SAMD13 grouped by Sugar mediated signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SAMD13 →	+0.710	+1.153	.001	.001	3	4
KIDNEY	SKAP1 →	-1.726	-0.737	.002	.004	3	4
BONE	TLE1 →	-2.444	-1.353	<.001	<.001	3	4
BLOOD_Leukemia	UHRF1 →	-1.885	-1.157	.002	.004	3	4
LUNG_NSCLC_LUAD	WWC1 →	-0.940	-0.544	.004	.004	3	3
STOMACH	CXXC1 →	+0.817	+1.117	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SAMD13 by Sugar mediated signaling pathway activity — BONE

Explore this box plot interactively →