Sugar mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Sugar mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP1B1, FRAT2, and KREMEN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sugar mediated signaling pathway activity versus CYP1B1 in LUNG_SCLC (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CYP1B1 →	+2.942	+0.245	<.001	.007	3	2
LUNG_SCLC	FRAT2 →	-1.067	-0.275	<.001	.001	3	2
BLOOD_Lymphoma	KREMEN2 →	+3.046	+0.303	<.001	.001	3	2
LARGE_INTESTINE	LMTK3 →	+0.831	+0.330	.002	.007	3	2
LARGE_INTESTINE	TMED1 →	-0.625	-0.348	.009	.003	3	2
BREAST	EFHD2 →	-1.927	-0.375	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010182 vs CYP1B1 — LUNG_SCLC

Explore this scatter interactively →