Embryonic body morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic body morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPM2AIP1, FERMT2, and ISG20, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic body morphogenesis activity versus EPM2AIP1 in UCEC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EPM2AIP1 →	+0.529	+0.069	.002	.003	3	8
COAD	FERMT2 →	+0.633	+0.070	<.001	<.001	3	7
BRCA	ISG20 →	-0.576	-0.044	<.001	.001	3	7
LSCC	MLKL →	-0.415	-0.049	<.001	.003	3	7
LSCC	PSME2 →	-0.210	-0.043	.004	<.001	3	7
UCEC	PTMS →	+0.360	+0.052	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010172 vs EPM2AIP1 — UCEC

Explore this scatter interactively →