Embryonic body morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFB1I1, ZCCHC24, and CALHM5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic body morphogenesis activity versus TGFB1I1 in OV (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TGFB1I1 →	+0.821	+0.524	<.001	<.001	3	7
PDAC	ZCCHC24 →	+0.691	+0.899	<.001	<.001	3	7
OV	CALHM5 →	+0.737	+0.640	<.001	<.001	3	7
OV	DDR2 →	+1.245	+0.647	<.001	<.001	3	7
COAD	MSRB3 →	+1.007	+0.520	<.001	.001	3	7
PDAC	TCEAL7 →	+0.662	+1.102	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010172 vs TGFB1I1 — OV

Explore this scatter interactively →