Embryonic body morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRIN2D, DPM2, and ISG20L2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic body morphogenesis activity versus GRIN2D in STOMACH (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GRIN2D →	-2.962	-0.270	.003	.005	3	4
OESOPHAGUS	DPM2 →	-0.647	-0.259	.004	.007	3	3
OESOPHAGUS	ISG20L2 →	-0.852	-0.338	.001	.006	2	4
SKIN	SLC35F5 →	+0.961	+0.286	<.001	.008	3	3
SKIN	DDX41 →	-0.815	-0.329	.006	.004	3	3
CNS	RAD9A →	-0.861	-0.193	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010172 vs GRIN2D — STOMACH

Explore this scatter interactively →