Body morphogenesis

Across TCGA patient cohorts, RNA activity of the Body morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMCN1, FERMT2, and FMNL3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Body morphogenesis activity versus HMCN1 in COAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HMCN1 →	+0.672	+0.036	.001	.003	3	9
COAD	FERMT2 →	+0.625	+0.040	<.001	<.001	3	8
COAD	FMNL3 →	+0.427	+0.033	<.001	.003	3	8
UCEC	GEM_S23 →	+0.979	+0.113	<.001	<.001	3	8
COAD	LAMC1 →	+0.540	+0.037	<.001	<.001	3	8
COAD	MYLK →	+0.675	+0.032	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010171 vs HMCN1 — COAD

Explore this scatter interactively →