Body morphogenesis

Across TCGA patient cohorts, RNA activity of the Body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD1, ZFP14, and MMP16, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Body morphogenesis activity versus FZD1 in COAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FZD1 →	+0.650	+0.840	<.001	.001	3	6
BRCA	ZFP14 →	+0.496	+0.587	.001	.001	3	6
BRCA	MMP16 →	+0.772	+0.585	<.001	.001	3	6
OV	RBFOX2 →	+0.655	+0.809	.007	.002	2	7
COAD	NRK →	+0.934	+0.767	<.001	<.001	3	6
OV	FKBP7 →	+0.478	+0.542	.005	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010171 vs FZD1 — COAD

Explore this scatter interactively →