Body morphogenesis

Across TCGA cell cohorts, RNA activity of the Body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX2, ERGIC1, and FAM50B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOX2 grouped by Body morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SOX2 →	+2.513	+1.039	.003	.003	2	5
SKIN	ERGIC1 →	-0.463	-0.858	<.001	.006	3	3
CNS	FAM50B →	-1.845	-1.031	.001	.003	3	3
CNS	FARS2 →	-0.347	-0.776	.001	<.001	3	3
BLOOD_Leukemia	MLF2 →	+0.649	+0.382	<.001	<.001	3	3
PANCREAS	THNSL1 →	-0.629	-0.863	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOX2 by Body morphogenesis activity — CNS

Explore this box plot interactively →