Body morphogenesis

Across TCGA cell cohorts, RNA activity of the Body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP12, LPAR2, and OSBPL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Body morphogenesis activity versus RRP12 in LUNG_SCLC (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RRP12 →	-0.841	-0.910	.005	.009	3	4
BLOOD_Leukemia	LPAR2 →	-1.724	-1.336	<.001	<.001	3	4
BLOOD_Leukemia	OSBPL3 →	+1.340	+1.223	<.001	<.001	3	4
BLOOD_Lymphoma	STRADB →	-1.006	-0.717	.004	.001	3	4
BLOOD_Lymphoma	E2F1 →	+1.608	+0.996	<.001	.001	3	3
LUNG_SCLC	SEMA3G →	-1.222	-1.069	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010171 vs RRP12 — LUNG_SCLC

Explore this scatter interactively →