Response to X-ray

Across TCGA cell cohorts, RNA activity of the Response to X-ray pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF1, GYS1, and TGFBI, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSF1 grouped by Response to X-ray-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CSF1 →	-2.429	-0.254	.003	.003	2	6
LIVER	GYS1 →	+1.434	+0.434	.008	.002	3	5
BONE	TGFBI →	-4.686	-0.254	<.001	.003	3	4
LUNG_NSCLC_LUAD	ETNK1 →	+0.561	+0.167	.003	.002	3	4
BREAST	ACBD4 →	+0.878	+0.172	.003	.007	3	4
OESOPHAGUS	JDP2 →	-1.396	-0.242	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSF1 by Response to X-ray activity — BONE

Explore this box plot interactively →