Response to X-ray

Across TCGA cell cohorts, RNA activity of the Response to X-ray pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN25, DHX33, and ZNF143, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to X-ray activity versus ZSCAN25 in LUNG_NSCLC_LUSC (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZSCAN25 →	+0.963	+0.186	.009	.002	3	6
OESOPHAGUS	DHX33 →	+1.113	+0.198	.001	.003	3	5
URINARY_TRACT	ZNF143 →	+0.443	+0.365	.005	.007	3	5
LARGE_INTESTINE	NUDT3 →	+0.644	+0.150	<.001	<.001	3	5
LUNG_NSCLC_LUSC	MRTFA →	+2.063	+0.277	.004	.005	3	5
BREAST	ZFP69B →	+0.848	+0.227	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010165 vs ZSCAN25 — LUNG_NSCLC_LUSC

Explore this scatter interactively →