Specification of animal organ identity

Across TCGA patient cohorts, RNA activity of the Specification of animal organ identity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EZH2_T367, SORBS1, and SMC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Specification of animal organ identity activity versus EZH2_T367 in LSCC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EZH2_T367 →	-0.759	-0.054	.003	.002	3	9
BRCA	SORBS1 →	+0.536	+0.035	<.001	<.001	3	8
BRCA	SMC2 →	-0.430	-0.040	<.001	<.001	3	8
LUAD	DHFR →	-0.482	-0.046	<.001	<.001	3	8
BRCA	MACROH2A1_T129 →	-0.640	-0.061	<.001	<.001	3	8
LUAD	BRIP1_T989 →	-1.084	-0.062	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010092 vs EZH2_T367 — LSCC

Explore this scatter interactively →