Specification of animal organ identity

Across TCGA patient cohorts, RNA activity of the Specification of animal organ identity pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFATC4, ACSS3, and MFAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Specification of animal organ identity activity versus NFATC4 in UCEC (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NFATC4 →	+0.771	+0.248	.006	.002	3	5
BRCA	ACSS3 →	+1.035	+0.626	<.001	.008	3	5
UCEC	MFAP4 →	+1.546	+0.254	<.001	.004	3	5
UCEC	DIO3OS →	+0.763	+0.253	.002	.002	3	5
PDAC	MEOX2 →	+0.766	+0.404	<.001	.004	3	5
PDAC	HMCN1 →	+0.580	+0.389	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010092 vs NFATC4 — UCEC

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