Response to manganese ion

Across TCGA patient cohorts, RNA activity of the Response to manganese ion pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP7A, EIF2AK3, and LRRC37A15P, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to manganese ion activity versus ATP7A in UVM (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ATP7A →	+1.191	+0.057	<.001	<.001	3	29
UVM	EIF2AK3 →	+1.103	+0.061	<.001	<.001	3	29
THYM	LRRC37A15P →	+0.713	+0.064	<.001	<.001	3	29
THYM	EBLN2 →	+0.925	+0.063	<.001	<.001	3	29
UVM	SEL1L →	+1.238	+0.062	<.001	<.001	3	29
THYM	SUSD6 →	+1.174	+0.055	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010042 vs ATP7A — UVM

Explore this scatter interactively →