Response to manganese ion

Across TCGA patient cohorts, RNA activity of the Response to manganese ion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC16A3, ATP13A3, and ZC3H18_S534, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to manganese ion activity versus SLC16A3 in UCEC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC16A3 →	+0.708	+0.525	<.001	<.001	3	4
PDAC	ATP13A3 →	+0.363	+0.615	<.001	<.001	3	4
OV	ZC3H18_S534 →	-1.187	-0.958	<.001	<.001	3	4
PDAC	LTB4R_S320 →	+0.917	+0.644	<.001	.001	3	4
UCEC	SLC12A7 →	+0.537	+0.485	<.001	<.001	3	3
UCEC	SLC16A3_S436 →	+0.910	+0.662	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010042 vs SLC16A3 — UCEC

Explore this scatter interactively →