Response to manganese ion

Across TCGA cell cohorts, RNA activity of the Response to manganese ion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F7, B3GLCT, and DSE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, E2F7 grouped by Response to manganese ion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	E2F7 →	-1.112	-0.219	.003	.004	3	5
PANCREAS	B3GLCT →	+0.907	+0.312	<.001	<.001	3	4
LARGE_INTESTINE	DSE →	-1.088	-0.263	.001	.009	3	4
LUNG_NSCLC_LUSC	NIBAN1 →	-3.246	-0.393	<.001	.001	3	4
OESOPHAGUS	REST →	+0.656	+0.388	.004	.003	2	5
CNS	PARP4 →	-0.692	-0.588	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

E2F7 by Response to manganese ion activity — LARGE_INTESTINE

Explore this box plot interactively →