Response to manganese ion

Across TCGA cell cohorts, RNA activity of the Response to manganese ion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGUOK, TYMP, and NDUFB10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to manganese ion activity versus DGUOK in LUNG_NSCLC_LUAD (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DGUOK →	-0.620	-0.192	.004	.001	3	5
BREAST	TYMP →	+2.513	+0.226	<.001	<.001	3	5
BREAST	NDUFB10 →	-0.859	-0.218	<.001	<.001	3	5
BREAST	TAP1 →	+1.187	+0.174	.004	<.001	3	5
BREAST	PSMB8 →	+1.999	+0.184	.002	<.001	3	5
PANCREAS	IL32 →	+3.786	+0.272	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010042 vs DGUOK — LUNG_NSCLC_LUAD

Explore this scatter interactively →