Response to iron(II) ion

Across TCGA patient cohorts, RNA activity of the Response to iron(II) ion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1S, CTSH, and DKC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to iron(II) ion activity versus C1S in OV (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1S →	+0.455	+0.050	.002	.005	2	5
OV	CTSH →	+0.445	+0.054	.005	.002	3	4
OV	DKC1 →	-0.323	-0.055	.001	.003	3	4
BRCA	H6PD →	+0.391	+0.049	.002	.007	3	4
CCRCC	SYNE1_S6230 →	+1.915	+0.091	.001	.001	3	4
PDAC	SLIRP →	-0.442	-0.063	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010040 vs C1S — OV

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