Response to iron(II) ion

Across TCGA cell cohorts, RNA activity of the Response to iron(II) ion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COG3, CCDC13, and NCEH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COG3 grouped by Response to iron(II) ion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COG3 →	-0.635	-1.034	.002	.001	3	4
OESOPHAGUS	CCDC13 →	+0.243	+1.537	.005	.001	3	3
BLOOD_Myeloma	NCEH1 →	-0.830	-1.485	<.001	<.001	3	3
BLOOD_Leukemia	KDM4D →	-0.507	-1.316	.001	<.001	3	3
BLOOD_Myeloma	ALG3 →	-0.791	-1.490	.003	<.001	2	4
BLOOD_Myeloma	ANKRD20A1 →	+0.810	+1.307	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COG3 by Response to iron(II) ion activity — LARGE_INTESTINE

Explore this box plot interactively →