Response to iron(II) ion

Across TCGA cell cohorts, RNA activity of the Response to iron(II) ion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PP2D1, RDH14, and FOS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to iron(II) ion activity versus PP2D1 in BREAST (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PP2D1 →	-0.150	-2.159	.001	<.001	3	5
LUNG_SCLC	RDH14 →	-0.642	-1.276	.002	.006	2	4
LUNG_NSCLC_LUAD	FOS →	-3.763	-1.450	.001	.001	3	3
LUNG_NSCLC_LUAD	ZCCHC3 →	-0.771	-1.125	.001	.008	3	3
STOMACH	RBM25 →	-1.210	-1.718	.007	.009	2	4
BREAST	CPT1A →	-1.160	-1.632	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010040 vs PP2D1 — BREAST

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