Response to iron ion

Across TCGA patient cohorts, RNA activity of the Response to iron ion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PATL1, TOP1, and BSG, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to iron ion activity versus PATL1 in BRCA (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PATL1 →	-0.307	-0.074	<.001	<.001	3	7
GBM	TOP1 →	-0.365	-0.071	<.001	<.001	3	6
BRCA	BSG →	-0.355	-0.061	<.001	<.001	3	6
CCRCC	TNS2_S120 →	+0.450	+0.044	<.001	<.001	3	6
CCRCC	FRZB →	+0.921	+0.053	<.001	<.001	3	6
BRCA	SEPTIN4_S432 →	+0.438	+0.059	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010039 vs PATL1 — BRCA

Explore this scatter interactively →