Response to iron ion

Across TCGA cell cohorts, RNA activity of the Response to iron ion pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFRC, TFAP2A, and MXD4, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TFRC grouped by Response to iron ion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TFRC →	-0.652	-0.790	<.001	.003	3	13
KIDNEY	TFAP2A →	-0.259	-0.248	.005	.007	2	5
OESOPHAGUS	MXD4 →	-0.181	-1.694	<.001	<.001	3	4
LUNG_NSCLC_LUAD	FXN →	-0.266	-0.348	<.001	.005	3	4
LARGE_INTESTINE	AP2M1 →	-0.712	-0.445	<.001	.008	3	4
BLOOD_Lymphoma	A4GALT →	+0.246	+0.278	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TFRC by Response to iron ion activity — PANCREAS

Explore this box plot interactively →