Response to iron ion

Across TCGA cell cohorts, RNA activity of the Response to iron ion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME3, WRN, and NCS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NME3 grouped by Response to iron ion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NME3 →	+1.057	+0.262	.002	.004	3	6
UPPER_AERODIGESTIVE_TRACT	WRN →	-1.316	-0.337	<.001	.003	3	4
LUNG_NSCLC_LUAD	NCS1 →	-1.037	-0.318	.003	.007	3	4
LUNG_NSCLC_LUAD	KIF21B →	-0.908	-0.352	.002	.008	3	4
SKIN	RPL5 →	-0.523	-0.286	.003	.002	3	4
CNS	PRKCI →	-0.482	-0.678	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NME3 by Response to iron ion activity — BREAST

Explore this box plot interactively →