Response to iron ion

Across TCGA cell cohorts, RNA activity of the Response to iron ion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQSTM1, MGAT4B, and B2M, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to iron ion activity versus SQSTM1 in LIVER (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SQSTM1 →	+1.912	+0.538	.001	<.001	3	6
LIVER	MGAT4B →	+1.162	+0.447	.005	.005	3	6
LIVER	B2M →	+1.610	+0.400	.005	.001	3	6
LIVER	SLC22A4 →	+2.494	+0.524	.007	<.001	3	6
URINARY_TRACT	NLRC5 →	+1.640	+0.257	.006	.004	3	5
CNS	HLA-C →	+2.231	+0.268	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010039 vs SQSTM1 — LIVER

Explore this scatter interactively →