Cardioblast differentiation

Across TCGA patient cohorts, RNA activity of the Cardioblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K5, ZC3H13, and GPATCH2L, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardioblast differentiation activity versus MAP4K5 in MESO (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	MAP4K5 →	+0.740	+0.067	<.001	<.001	3	28
UVM	ZC3H13 →	+1.691	+0.066	<.001	<.001	3	27
SARC	GPATCH2L →	+0.772	+0.050	<.001	<.001	3	27
THYM	NFAT5 →	+1.347	+0.068	<.001	<.001	3	26
DLBC	USP34 →	+1.637	+0.073	<.001	.001	3	26
SARC	LPP →	+1.073	+0.046	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010002 vs MAP4K5 — MESO

Explore this scatter interactively →