Cardioblast differentiation

Across TCGA patient cohorts, RNA activity of the Cardioblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBN1, BGN, and OLFML1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardioblast differentiation activity versus FBN1 in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FBN1 →	+1.121	+0.541	<.001	.002	3	6
GBM	BGN →	+1.101	+0.430	<.001	<.001	3	6
BRCA	OLFML1 →	+0.828	+0.462	<.001	.003	3	6
CCRCC	CARMN →	+0.596	+0.481	.003	<.001	3	6
HNSC	CD34 →	+0.510	+0.458	<.001	.001	3	6
UCEC	CXCL12 →	+0.850	+0.396	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010002 vs FBN1 — BRCA

Explore this scatter interactively →