Cardioblast differentiation

Across TCGA cell cohorts, RNA activity of the Cardioblast differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CREB3L1, ZFP69B, and ZFP62, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CREB3L1 grouped by Cardioblast differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CREB3L1 →	-0.229	-0.571	.005	.007	3	2
CNS	ZFP69B →	-0.348	-0.406	.003	.003	3	2
CNS	ZFP62 →	-0.256	-0.414	.004	.003	3	2
CNS	MYL6 →	-0.266	-0.406	.001	.003	3	2
LUNG_NSCLC_LUAD	DYRK1A →	-0.159	-0.756	.009	.002	3	2
LUNG_NSCLC_LUAD	EPB41L1 →	-0.094	-0.571	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CREB3L1 by Cardioblast differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →