Glial cell differentiation

Across TCGA patient cohorts, RNA activity of the Glial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, CTHRC1, and HSPA9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell differentiation activity versus VCAN in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VCAN →	+0.808	+0.021	<.001	.001	3	7
COAD	CTHRC1 →	+0.752	+0.015	.009	.006	3	7
OV	HSPA9 →	-0.405	-0.021	<.001	.001	3	7
BRCA	TIMP2 →	+0.572	+0.022	.002	<.001	3	7
BRCA	CNN2 →	+0.600	+0.035	<.001	<.001	3	7
BRCA	LOXL1 →	+0.473	+0.024	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010001 vs VCAN — OV

Explore this scatter interactively →