Oocyte differentiation

Across TCGA patient cohorts, RNA activity of the Oocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL5A2, SRRM2_S536, and SERPINH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oocyte differentiation activity versus COL5A2 in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COL5A2 →	+0.474	+0.030	.001	<.001	3	5
GBM	SRRM2_S536 →	+0.415	+0.034	.001	.008	3	5
LSCC	SERPINH1 →	+0.398	+0.040	<.001	<.001	3	4
LSCC	C1QA →	+0.371	+0.038	<.001	<.001	3	4
LSCC	C1QB →	+0.411	+0.035	<.001	<.001	3	4
LSCC	C1QC →	+0.424	+0.029	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009994 vs COL5A2 — OV

Explore this scatter interactively →