Oocyte differentiation

Across TCGA patient cohorts, RNA activity of the Oocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ING5, SPRTN, and TRIM23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oocyte differentiation activity versus ING5 in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ING5 →	+0.439	+0.586	.002	.002	3	4
PDAC	SPRTN →	+0.221	+0.514	.007	<.001	3	4
UCEC	TRIM23 →	+0.300	+0.564	.007	.003	3	4
LSCC	ADGRG3 →	-0.646	-0.681	.001	<.001	3	4
UCEC	LINC01506 →	-0.801	-0.708	<.001	<.001	3	4
LSCC	SUDS3 →	+0.415	+0.634	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009994 vs ING5 — OV

Explore this scatter interactively →