Intracellular water homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular water homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GAB1, GPD1, and WDR75_S782, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular water homeostasis activity versus GAB1 in OV (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GAB1 →	+0.478	+0.054	.001	.006	3	6
OV	GPD1 →	+1.117	+0.070	<.001	<.001	3	6
CCRCC	WDR75_S782 →	-0.610	-0.096	.007	.004	3	5
LSCC	ZC3H13_T1033 →	-0.208	-0.082	.004	.009	3	5
LUAD	LRWD1_S243 →	-1.190	-0.133	.005	<.001	3	5
HNSC	MAST4_S206 →	+0.560	+0.052	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009992 vs GAB1 — OV

Explore this scatter interactively →