Cell-cell recognition

Across TCGA patient cohorts, RNA activity of the Cell-cell recognition pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1, CCDC50, and CD4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell recognition activity versus SAMHD1 in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAMHD1 →	+0.615	+0.123	<.001	<.001	3	9
COAD	CCDC50 →	+0.281	+0.030	<.001	<.001	3	9
GBM	CD4 →	+0.726	+0.111	<.001	<.001	3	9
GBM	FYB1 →	+0.798	+0.113	<.001	<.001	3	9
GBM	RGS10 →	+0.497	+0.081	<.001	<.001	3	8
LSCC	SASH3 →	+0.593	+0.170	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009988 vs SAMHD1 — HNSC

Explore this scatter interactively →