Cell-cell recognition

Across TCGA patient cohorts, RNA activity of the Cell-cell recognition pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD226, PIK3R5, and TNFSF8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell recognition activity versus CD226 in BRCA (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD226 →	+0.397	+0.117	<.001	<.001	3	6
GBM	PIK3R5 →	+0.688	+0.054	.001	.002	3	6
GBM	TNFSF8 →	+0.589	+0.062	.001	<.001	3	5
BRCA	DOCK8 →	+0.638	+0.157	.001	<.001	3	5
GBM	BIN2 →	+0.628	+0.051	<.001	.001	3	5
GBM	CD86 →	+0.836	+0.058	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009988 vs CD226 — BRCA

Explore this scatter interactively →