Cell-cell recognition

Across TCGA cell cohorts, RNA activity of the Cell-cell recognition pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2E2, GEM, and MRPL54, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell recognition activity versus GTF2E2 in BLOOD_Myeloma (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GTF2E2 →	+0.942	+0.294	.001	<.001	3	6
OVARY	GEM →	+1.398	+0.275	.002	.001	3	6
OVARY	MRPL54 →	+0.983	+0.318	<.001	<.001	3	6
OVARY	MT-ND2 →	-0.751	-0.212	.004	.005	3	6
BREAST	LIX1L →	+1.443	+0.134	.001	.003	3	6
OVARY	DENND1C →	-2.701	-0.311	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009988 vs GTF2E2 — BLOOD_Myeloma

Explore this scatter interactively →