Proximal/distal pattern formation

Across TCGA patient cohorts, RNA activity of the Proximal/distal pattern formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FERMT2, ECM2, and NPHP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proximal/distal pattern formation activity versus FERMT2 in BRCA (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FERMT2 →	+0.787	+0.373	<.001	.002	3	5
BRCA	ECM2 →	+1.210	+0.511	<.001	.002	3	4
BRCA	NPHP3 →	+0.436	+0.387	<.001	<.001	3	4
LSCC	ITGAE →	-0.494	-0.352	.001	<.001	3	4
PDAC	MXRA5 →	+0.538	+0.357	.009	.004	3	4
BRCA	MEIS3 →	+1.179	+0.526	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009954 vs FERMT2 — BRCA

Explore this scatter interactively →