Proximal/distal pattern formation

Across TCGA cell cohorts, RNA activity of the Proximal/distal pattern formation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF3, UBE2B, and SEC23A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAF3 grouped by Proximal/distal pattern formation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TRAF3 →	-0.770	-0.926	.003	.003	3	4
LUNG_NSCLC_LUAD	UBE2B →	-0.514	-0.994	.001	.001	3	4
LUNG_NSCLC_LUSC	SEC23A →	-1.110	-1.031	.009	.005	3	4
BONE	EFEMP1 →	-4.952	-1.639	.008	.005	3	4
BONE	GLIPR1 →	-4.742	-2.124	.004	<.001	3	4
BONE	CCN1 →	-4.844	-1.734	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAF3 by Proximal/distal pattern formation activity — OESOPHAGUS

Explore this box plot interactively →