Epidermal cell differentiation

Across TCGA patient cohorts, RNA activity of the Epidermal cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RHBDF2_T175, SEC61B_S49, and SHANK3_S1413, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epidermal cell differentiation activity versus RHBDF2_T175 in COAD (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RHBDF2_T175 →	-0.511	-1.403	<.001	<.001	3	1
COAD	SEC61B_S49 →	-0.406	-0.892	.001	.002	3	1
COAD	SHANK3_S1413 →	-0.639	-1.398	.002	<.001	3	1
COAD	SLC15A4 →	-0.554	-0.603	<.001	.004	3	1
COAD	SLTM_S590 →	-0.543	-0.481	.005	.006	3	1
COAD	ATP2B4_S13 →	+0.484	+0.590	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009913 vs RHBDF2_T175 — COAD

Explore this scatter interactively →