Epidermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Epidermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT7, ALDH1A3, and OLFML2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epidermal cell differentiation activity versus KRT7 in LARGE_INTESTINE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRT7 →	+2.635	+0.214	.002	<.001	3	6
LARGE_INTESTINE	ALDH1A3 →	+2.786	+0.212	<.001	<.001	3	5
LARGE_INTESTINE	OLFML2A →	+0.960	+0.263	.001	<.001	3	5
STOMACH	TMEM97 →	-1.112	-0.200	.004	.005	3	5
PANCREAS	SCEL →	+3.707	+0.279	<.001	.001	3	5
KIDNEY	APOO →	-1.307	-0.359	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009913 vs KRT7 — LARGE_INTESTINE

Explore this scatter interactively →