Post-embryonic animal morphogenesis

pathway activity — cross-omics
GO:0009886Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Post-embryonic animal morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHISA2, CEACAM5, and CYP4F3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADSHISA2 →+0.716+0.740.001.00334
UCECCEACAM5 →-1.733-0.625<.001.00133
UCECCYP4F3 →-0.975-0.746.004<.00133
CCRCCCSRNP1 →-0.512-0.660.007<.00133
CCRCCRNA5SP304 →-1.037-0.750<.001.00233
OVIZUMO4 →+0.400+0.551.006.00433
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration