Embryonic pattern specification

Across TCGA patient cohorts, RNA activity of the Embryonic pattern specification pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARP14, PSME2, and FERMT3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic pattern specification activity versus PARP14 in COAD (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PARP14 →	-0.308	-0.019	<.001	<.001	3	8
COAD	PSME2 →	-0.376	-0.023	.001	<.001	3	8
LSCC	FERMT3 →	-0.367	-0.034	<.001	<.001	3	7
COAD	PSMB10_S230 →	-0.569	-0.027	<.001	<.001	3	7
HNSC	CENPV →	+0.463	+0.031	<.001	.002	3	7
LUAD	GBP5 →	-0.659	-0.028	.002	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009880 vs PARP14 — COAD

Explore this scatter interactively →