Embryonic pattern specification

Across TCGA cell cohorts, RNA activity of the Embryonic pattern specification pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SATB2, GPR162, and TRIP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SATB2 grouped by Embryonic pattern specification-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SATB2 →	-0.222	-0.959	.005	.001	1	8
LUNG_SCLC	GPR162 →	-0.363	-0.994	.003	.004	3	5
CNS	TRIP4 →	-0.228	-1.100	<.001	<.001	3	5
CNS	FZD5 →	-0.188	-0.986	.001	<.001	3	5
CNS	CELA2B →	-0.209	-0.811	.007	.001	3	5
LUNG_NSCLC_LUAD	IHH →	-0.254	-0.794	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SATB2 by Embryonic pattern specification activity — CNS

Explore this box plot interactively →