Embryonic pattern specification

Across TCGA cell cohorts, RNA activity of the Embryonic pattern specification pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35B2, SIRT7, and SCHIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC35B2 grouped by Embryonic pattern specification-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC35B2 →	-0.641	-0.674	<.001	.005	3	4
BLOOD_Lymphoma	SIRT7 →	-1.325	-2.030	<.001	<.001	3	4
LUNG_SCLC	SCHIP1 →	-3.642	-1.062	.001	.002	3	4
LUNG_SCLC	TOR3A →	+1.605	+1.471	<.001	<.001	3	4
BONE	CCDC96 →	-0.586	-0.925	<.001	.007	2	4
BLOOD_Lymphoma	KAT8 →	-0.693	-2.221	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC35B2 by Embryonic pattern specification activity — PANCREAS

Explore this box plot interactively →