Embryonic pattern specification

Across TCGA cell cohorts, RNA activity of the Embryonic pattern specification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, TIMP2, and MAPKAPK5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic pattern specification activity versus BASP1 in LUNG_NSCLC_LUSC (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	BASP1 →	+5.637	+1.937	.001	<.001	3	10
LIVER	TIMP2 →	+2.447	+1.948	<.001	<.001	3	6
BLOOD_Lymphoma	MAPKAPK5 →	-0.427	-1.334	.002	.003	3	5
LIVER	SRGN →	+5.696	+1.547	.005	.002	3	5
LIVER	PRR5L →	+3.972	+1.873	<.001	<.001	3	5
BREAST	PTX3 →	+3.345	+1.420	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009880 vs BASP1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →