Abscission

pathway activity — cross-omics
GO:0009838Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Abscission pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCLS1, BLK, and LINC01508, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCHCLS1 →-0.730-0.153.006.00134
CCRCCBLK →-0.397-0.197<.001.00625
COADLINC01508 →+0.071+0.158.001.00134
UCECTRBV10-3 →-0.576-0.147.005.00134
UCECFGR →-0.644-0.184.005.00134
HNSCIFFO1 →-0.327-0.139.008<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration