Alkaloid metabolic process

Across TCGA patient cohorts, RNA activity of the Alkaloid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF740, NNMT, and EDRF1, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alkaloid metabolic process activity versus ZNF740 in DLBC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ZNF740 →	-1.105	-0.260	<.001	<.001	3	25
CHOL	NNMT →	+2.181	+0.127	.001	.004	1	27
DLBC	EDRF1 →	-1.279	-0.272	<.001	<.001	3	23
ACC	ILF3 →	-0.987	-0.141	<.001	<.001	3	23
SCLC	TAF5 →	-0.703	-1.142	<.001	<.001	3	23
DLBC	LSM14B →	-1.317	-0.269	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009820 vs ZNF740 — DLBC

Explore this scatter interactively →